Propofol Infusion Syndrome in Adults: A Clinical Update

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Propofol Infusion Syndrome in Adults: A Clinical Update

Propofol infusion syndrome is a rare but extremely dangerous complication of propofol administration. Certain risk factors for the development of propofol infusion syndrome are described, such as appropriate propofol doses and durations of administration, carbohydrate depletion, severe illness, and concomitant administration of catecholamines and glucocorticosteroids. The pathophysiology of thi...

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Propofol infusion syndrome: update of clinical manifestation and pathophysiology.

Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion. The purpose of this review was to provide a new update of reported case reports and to describe recent retrospective studies...

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Propofol infusion syndrome.

The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol.l(-1)), rhabdomyolysis, hyperlipidaemia, and enlarged or fatty liver. There is an association between PRIS and propofol infusions at doses higher than 4 mg.kg(-1).h(-1) for greater than 48 h d...

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Propofol Infusion Syndrome or Probable Overinterpretation Syndrome?

To the Editor:—It was with great interest that we read the article by Cravens et al. on the incidence of propofol infusion syndrome. This is obviously an important question with significant clinical relevance. However, with all of the inherent limitations of a retrospective study as recognized by the authors, we find the interpretation and conclusion of the authors (“this study provides evidenc...

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Propofol infusion syndrome or probable overinterpretation syndrome?

To the Editor:—It was with great interest that we read the article by Cravens et al. on the incidence of propofol infusion syndrome. This is obviously an important question with significant clinical relevance. However, with all of the inherent limitations of a retrospective study as recognized by the authors, we find the interpretation and conclusion of the authors (“this study provides evidenc...

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ژورنال

عنوان ژورنال: Critical Care Research and Practice

سال: 2015

ISSN: 2090-1305,2090-1313

DOI: 10.1155/2015/260385